So, who does O'Neill bring in to replace the missing stars? There is no word yet on the fitness of Henrik Larsson and if the Swede is forced to sit out the game again there could be a surprise inclusion of Shaun Maloney in the starting line up.
In defence, O'Neill may have to risk bringing back Joos Valgaeren ahead of schedule. The big Belgian is resting an abdominal injury but may be needed now that Sutton can no longer fill in for him at the back. The other option is to draft in Stephen Crainey. The youngster has done well in his previous outings in the first team and O'Neill may well risk him.
The forward line will be O'Neill's biggest worry though. If Hartson, Sutton and Larsson are all out then he is left with very few options up front. A strikeforce of Maloney and Moravcik may seem very lightweight but in the circumstances it may be all that O'Neill has to work with.
On Monday Stillan Petrov played a far more advanced midfield role than of late and the odds are on the Bulgarian being asked to repeat it again. Stillian did very well on Monday, notching a goal and causing the Dons defence a lot of problems in the process.
Aberdeen will be up for this game big style and coupled with Celtic's injuries it should make for an entertaining ninety minutes.