Attackers Raffael and Thorgan Hazard and defender Andreas Christensen are out through injury, while USA international Fabian Johnson did not travel to Glasgow for the Group C clash due to illness.
Rodgers' side go into the game unbeaten domestically and on the back of an encouraging 3-3 draw with Manchester City last month.
Consequently the chances of a home win, which would go a long way to ensuring the Hoops remain in Europe after Christmas, is not as fanciful as it might have been after the 7-0 defeat by Barcelona on match day one.
However, the former Swansea and Liverpool boss insists the Germans have enough players of quality to call upon.
He said: "It's always an opportunity for someone else.
"Like ourselves, if we have players missing there's always others to step in.
"It'll be exactly the same for them
They have outstanding players and I am sure they have a squad there who can come in.
"They are still going to be a very good team.
"They play 3-4-3 so offensively they always have numbers around the ball.
"They like to work and press so it should be a really good game and we have to find the solutions to exploit that."
Monchengladbach boss Andre Schubert, looking for his first points after defeats to City and Barcelona, is confident he has enough quality in his squad to get a positive result at Celtic Park.
"It is always going to be difficult without certain key players, especially the best scorers and players in defence," he said.
"But we have good players to come in and we believe they can do well
Hopefully we can get an excellent result.
"We are going to meet with a lot of passion from the fans.
"This will be a big challenge but we need to make an impact and be aggressive."
Source : PA
Source: PA